Short Answer
Ketamine therapy can be safe when used under medical supervision, but it's essential to understand its potential risks and benefits.
What This Means
You may experience a range of emotions and physical sensations during ketamine therapy, including feelings of relaxation, euphoria, or even anxiety. This is because ketamine affects the nervous system, which can be overwhelming if you're not prepared.
During ketamine therapy, you may also experience a resurgence of past traumatic memories or emotions, which can be distressing. It's essential to work with a trained therapist who is experienced in trauma-informed care and can provide a safe and supportive environment for processing these experiences. By doing so, you'll have the opportunity to confront and integrate your traumatic experiences in a way that promotes healing and growth.
Why This Happens
Research on the stress response shows that ketamine can trigger a release of certain neurotransmitters in the brain, leading to changes in mood and perception. Additionally, the nervous system's natural response to stress or trauma can be triggered by ketamine, causing feelings of anxiety or discomfort.
The exact mechanisms behind ketamine's effects on the nervous system are complex and not yet fully understood. However, it's thought that ketamine may alter the activity of certain brain regions involved in emotional processing and memory consolidation.
What Can Help
- Establish a rapport with your therapist**: Building trust and a strong therapeutic relationship can help you feel more comfortable during ketamine therapy.
- Communicate openly about your experiences**: Share any concerns or discomfort you're feeling with your therapist, so they can adjust the treatment plan as needed.
- Stay hydrated and follow aftercare instructions**: Drinking plenty of water and following post-treatment guidelines can help minimize potential side effects.
- Be aware of your mental health history**: If you have a history of trauma or mental health conditions, discuss this with your therapist to ensure they're taking necessary precautions.
- Seek support from loved ones**: Having a supportive network can help you feel more grounded and secure during the ketamine therapy process.
When to Seek Support
If you experience any severe side effects, such as increased anxiety or suicidal thoughts, seek immediate medical attention.
If you're struggling to cope with the emotional demands of ketamine therapy, don't hesitate to reach out to your therapist or a trusted support system for help.
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This content draws from peer-reviewed research and established clinical frameworks.
Primary Research
- Zaki, N. Chen, L. Lane, R. et al. (2026). Long-Term Safety and Maintenance of Response With Esketamine Nasal Spray in Participants With Treatment-Resistant Depression: Interim Results of the SUSTAIN-3 Study.. Focus (American Psychiatric Publishing). [PubMed]
- Kosik-Gonzalez, C. Fu, D. Chen, L. et al. (2026). Effect of Esketamine on Depressive Symptoms in Adolescents With Major Depressive Disorder at Imminent Suicide Risk: A Randomized Psychoactive-Controlled Study.. Focus (American Psychiatric Publishing). [PubMed]
- Wang, D. Gai, Q. Zhang, Y. et al. (2026). The Effect of Esketamine Combined with Pulsed Radiofrequency on Neuropathic Pain in Herpes Zoster Patients: A Randomised Clinical Trial.. Pain and therapy. [PubMed]
- Fremont, R. Corwin, M. Kandel, G. et al. (2026). Emerging Clinical Applications of Ketamine and Esketamine Across Psychiatric Disorders.. Focus (American Psychiatric Publishing). [PubMed]
Foundational Authorities
Robert Greene
Author, Founder, Navy Veteran & Trauma Survivor
Robert Greene is a writer and strategist focused on human behavior, relationships, and personal development. Drawing from lived experience, global travel, and diverse perspectives, he explores the patterns driving how people think, connect, and self-sabotage. His work challenges conventional narratives around mental health, modern relationships, and personal growth. Because awareness is where real change begins.
